I ride it every so often but my main ride is a 36er with a comfortable “normal” saddle. I have put a 100 mile day on it with no padded shorts and no adverse effects what so ever.
The noseless air saddle is by far the most comfortable as far as the saddle goes but there are issues with it. A minor issue is that it is harder to mount because you have to get over/around the saddle and kind of slip down into it from above.
The more serious adverse problem with it is that the seat has to be lower then ideal. In order to sit on the noseless saddle the legs have to be flexed more then ideal when the pedal is at the bottom of the stroke. It is a trade off, on a normal uni saddle your leg can be nearly straight when at the bottom of the stroke but the price you pay for that is putting more pressure on the center of your crotch. On a bicycle the pedals are forward of the saddle and this type of saddle would work better then a unicycle where to pedals are directly below the saddle.
I’m still thinking of alternate ways to put more pressure on the front that would allow more free movement of the legs. Early bicycles that had free motion of the legs had a quite large front support.
A more modern idea but along the same lines in a GlideTrak tm support system it has a larger front/pelvic pad support then my noseless groin support and allows free leg moment.
The bottom line is that you need some kind of front support to hold you back on the saddle and sit bones. That may be push back from a handlebar, a normal uni saddle with some weight on the crotch, a groin support as on my noseless saddle, a pelvic pad as on the GlidTrak or a full belly support as on the first bicycles.