It’s certainly possible, but the learning curve will be steep.
After 35-ish years of almost exclusively riding a 20er I bought a 26" fatty (that’s about the same diameter than a 29x2"). It was a big step but I got accustomed to that within a couple weeks. The step from a 29er to a 36er was at least as big as going from 20" to 29".
You can read about my 36er experience here, if you want.
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