Why not? I mean just modify it of course, but I mean that sort of idea. Without flanges.
you would need to modify the idea of it. Not the hub itself. Maybe make your own hub similar to it?
I am guessing that you have to take the hub shell off the axle to lace. That would be a pain to do with a unicycle as you also have bearings to deal with.
Having it removable like that would introduce yet another place where the hub would be likely to develop some slop over time. I could be totally wrong about removing the shell to lace though I don’t see how else to do it with that hub.
Spokes would be harder to get and you might have to have them custom cut.
In some situations it may be easier to replace a broken spoke. (spokes on the far side do not get in the way)
It would build a stronger wheel that stays true longer and does not require as much stress relieving after being built. (shorter break in period)
Stiffer wheel.
No more bent flanges.
Seems like a really cool idea, high flanges are usually used to create a more rigid wheel so a wheel w/o flanges (or low flanges) would be noticeably more flexy than a hub with flanges similar to a normal uni hub. If you created an angled (high) flange hub designed for straight-pull spokes, all the spokes could load easily from the outside and create a strong wheel with good rigidity. The manufacturing process would require more machining, and might be slightly heavier, however the flanges could be made lighter (larger or more cutouts) due to the straight pull on the flange.
Actually, this hub does use normal spokes. They don’t come out of the hub radially, it’s designed for a 4-cross pattern (hence the offset holes… you wouldn’t need that for radial lacing). The shoulder of the spoke is the part that sits in the hole, and the spoke lays tangent to the outside of the hub. I saw one on my friend’s bmx bike a month or so ago… I think he said it’s great for not screwing up spokes during grinds.
Awesome design, but I think it’d be a little hard to make work with a unicycle hub.
EDIT: This is the one my friend has… I think it’s the company that first came out with the idea
Very Interesting Concept
That is a very cool Hub desing and I enjoyed the Idea.
I guess that a hub can be manufactured where an outer sleve slides on to the axle after the spokes have been interted. It could even be based on the ISIS standard! You therefore have an axle that has ISIS ridges on the whole length. You insert the spokes into the sleve, slide the sleve over the axle slide the bearings and spacers over the Axle and then attach the cranks. The radial lacing looks pretty cool but as mentioned above strait spokes would be even stronger. Once again a very cool Idea. I am still waiting to hear more about that 3 speed Fixie hub too! I think that we are going to see some really nice inovations in the next 5 years!
Unicorn
Shimano do a flangeless mountainbike hub, i have used it with no issues, the spokes just hook into the slots in the hub body
Notice any positives or negatives?
When riding sloppy trials (my specialty), one ends up bashing their hub flanges into the edge of whatever obstacle they’re trying to crank grab.
Without a hub flange, the spokes would be absorbing the impact of the obstacle. I don’t think the spokes would appreciate this.
I dont there would be much of a difference, other than looks. You always bash your spokes some, and they always eventually seem to get a wrapped look around your flanges, so how would this be any different.
You don’t even need to crank grab thing. My kh08 hub was vent silly even before I crank grabs.
See what i mean? Hehe 
The wheel is a lot easier to lace up as the spokes just clip into the hub instead of you having to thread them through altho you can only use a 3 cross spoke pattern with the hub, the ride is no different to normal hubs
http://www.danscomp.com/512085.php?cat=PARTS
Just simply mod the hole to fit onto the unicycle’s bottom bracket-like hub.
good idea but I can’t see where it would fit, you need 12.5 mm of bare axle to slide that thing on, whihc I don’t think I’ve ever seen on a unicycle.
That’s a sweet idea, why not suggest it Kris or UDC? I bet they’d consider selling an aftermarket bearing cap if folks would buy it. Another possibility would be nylon piece that clips onto the bearing cap. How about desiging the grind “wedge” to mount between the bearing holders? Made right, it would be like a grind rail for your uni, polyethylene slides nice 
Then try these,
http://www.danscomp.com/512115.php?cat=PARTS
http://www.danscomp.com/512061.php?cat=PARTS
This one probably best since it meant for a small space;
http://www.danscomp.com/512100.php?cat=PARTS
then there is,
http://www.danscomp.com/512116.php?cat=PARTS
http://www.danscomp.com/512044.php?cat=PARTS (good one)
http://www.danscomp.com/512045.php?cat=PARTS
Lastly
http://www.danscomp.com/512130.php?cat=PARTS
I already suggested that idea to Kris Holm a year ago, but still haven’t seen it happen.