The ISIS crank availability “advantage”, unfortunately, is a deceptive one, since the range of ISIS-compatible cranks out there is largely limited to 170-175mm lengths. If the rider does not need those lengths, the (current) ISIS crank availability situation is not much of a driving consideration.
For the ISIS, KH, and Profile hubs, the question is, what crank lengths does the hub manufacturer supply that are compatible with its hub? A refinement of this question also asks, for which applications?
This is not the place for a full discussion of this topic; the main thing is for the consumer to think of his/her specific application (i.e., “I’m a small guy doing trials but prefer low cadences”, or “I’m a tall woman doing extreme off-road and can spin like heck”), and consider the range of cranks that are suitable for that application from each hub supplier. This range, for the KH and Koxx, is 4-5 lengths that span a reasonable portion of the unicycling market’s needs. For the Profile, this is 10 lengths that cover the longer range more thoroughly, and is limited in the shorter range to 145mm. If you are primarily a MUni rider, then being able to purchase a 125mm crankset is irrelevant to you, and you might appreciate the refinement that is available from the Profile line. For instance, some riders use 165 or 160mm cranks on their 24" MUnis. If you are doing mod trials and are a small person, then you might want to use 125mm cranks on your trials setup, and choose the KH or Koxx instead. Finally, the same rider might want to swap cranks for different purposes. Participating in a 24 hour race might prompt a rider to swap in shorter cranks for more speed.
However, if the ISIS 170-175mm predominance fits the rider’s needs, then he/she has a HUGE selection, and this is a great advantage. A small caveat is that (again) most ISIS cranks are designed for road bicycle use. However, there are exceptions, such as the Bonz trials cranks, which come in 160 and 170mm.
I’ve also been glad to see and test some trials-quality square taper cranks, such as the Profile trials 158mm, and the Middleburn 165-180mm trials cranks. These cranks work very well on the 36" unis that LiveWire supplies to customers, and are integral to the Outta Phaze unicycle. The Middleburn crankset is the practical successor to the Kooka crankset that was so popular. They are also available with the ISIS interface. Please contact us for more information or to purchase these fine cranks.